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      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
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      <image:title>Home - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
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  </url>
  <url>
    <loc>https://www.gbulab.com/publications</loc>
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  </url>
  <url>
    <loc>https://www.gbulab.com/lab-members-1</loc>
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    <lastmod>2025-10-15</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/81a14fea-5931-4f2d-bc87-489e810d4b34/GJB_HKUST.jpg</image:loc>
      <image:title>LAB MEMBERS - Principal Investigator Prof. Guojun Bu</image:title>
      <image:caption>The Head, Division of Life Science, HKUST Lo Ka Chung Charitable Foundation Professor of Science Chair Professor PhD, Virginia Tech</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/84409c0e-21bf-4cf4-ad20-1f0e1047c8aa/Mandy_squared.jpeg</image:loc>
      <image:title>LAB MEMBERS - Mandy C.M. Chan ✉️ Lab Manager</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/bd60c849-51b8-4ba9-8812-ed4c7d0b7cb4/%E5%9B%BE%E7%89%87+1.jpg</image:loc>
      <image:title>LAB MEMBERS - Make it stand out</image:title>
      <image:caption>SAI KUNG HOI, HONG KONG, 09/DEC/2024</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/ce7a993d-423e-49e5-8a4c-2022f3841a7e/Jeff_v3.jpg</image:loc>
      <image:title>LAB MEMBERS - Jeff Y.L. Lam, PhD ✉️ University of Cambridge</image:title>
      <image:caption>Jeff</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/8591ff1a-5672-46dd-ba48-4c2c3e818b90/kai.jpg</image:loc>
      <image:title>LAB MEMBERS - Kai Wang, PhD ✉️ The University of Tokyo</image:title>
      <image:caption>Kai grew up in Northeast China and obtained his Ph.D. from the University of Tokyo, where he studied the molecular mechanisms underlying protective gene variants in Alzheimer’s disease. In the Bu Lab, his research focuses on APOE protective variants and aims to elucidate their molecular and cellular mechanisms using iPSC-derived cells and animal models. Outside the lab, he enjoys cooking and exploring nature.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/60e79266-e370-4380-a182-d49173c831e4/Lairai.jpg</image:loc>
      <image:title>LAB MEMBERS - Hao-Jie Chen, PhD ✉️ Beijing Normal University</image:title>
      <image:caption>Haojie investigates how genetic and lifestyle factors shape the early development of Alzheimer’s disease, the leading cause of dementia. By integrating large-scale human data with functional experiments, he aims to advance APOE-targeted predictive models and therapeutic strategies to promote brain health and mental well-being in the ageing population.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/610205ed-1705-4791-aa7f-a962591b0e5b/Oscar.jpg</image:loc>
      <image:title>LAB MEMBERS - Oscar W.H. Chua, PhD ✉️ Hannover Medical School</image:title>
      <image:caption>Oscar received his PhD trainings at the Hannover Medical School studying alpha synuclein-induced toxicity in Parkinson’s disease. Currently, by using iPSC and animal models, his research focuses on the roles of apoE and apoE receptors on the pathology and propagation of tau.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/74c158d4-8453-4e89-8a87-216e72ebc98a/Mia.jpg</image:loc>
      <image:title>LAB MEMBERS - Mia Yujing Liang ✉️ PhD student</image:title>
      <image:caption>This is Mia from Guangdong, Jiangmen. My projects are about evaluating the biochemical and biophysical patterns of artificially-generated apoE and cross-species apoE, paving the way to design for a super apoE as apoE-targeted gene therapy candidate.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/fbb17c85-ec0d-4aa2-8848-5b9d7fd42d46/Wenjun.jpg</image:loc>
      <image:title>LAB MEMBERS - Wenjun Zhang ✉️ PhD student</image:title>
      <image:caption>Wenjun received her M.S. from the University of Science and Technology of China. Her research focuses on iPSC-derived blood–brain barrier models and the peripheral effects of APOE on AD pathology.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/c8a6e39f-99ee-43f2-9153-c5bc13892268/Zhiyuan.jpg</image:loc>
      <image:title>LAB MEMBERS - Zhiyuan Ning ✉️ PhD student</image:title>
      <image:caption>Zhiyuan received his bachelor’s and master’s degree in Medicine from Sun Yat-Sen University. He investigates the roles of peripheral apoE using diverse approaches and animal models. His research also focuses on multi-omics analyses to explore the effects of APOE on Alzheimer’s disease, based on human samples and brain single-cell transcriptomes.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/de879ebd-beea-475a-a618-77d0f3a3344f/yalin.jpg</image:loc>
      <image:title>LAB MEMBERS - Yalin Zhu ✉️ Joint PhD student</image:title>
      <image:caption>Yalin earned her bachelor’s degree in biomedical engineering from Pennsylvania State University in 2017. She has contributed to the Greater Bay Area Healthy Aging Brain Study, and is studying APOE4-related biomarkers to enable the early detection of AD.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/93ae71d7-5eaf-4c6f-b784-2121edd6e42a/cong+li.jpg</image:loc>
      <image:title>LAB MEMBERS - Cong Li ✉️ Joint PhD student</image:title>
      <image:caption>Cong Li is a PhD student jointly trained by HKUST and Shenzhen Bay Laboratory. She obtained her master's degree from Sun Yat-sen University in 2022. Her research focuses on using Drosophila, iPSCs, and mice to develop potential therapeutic strategies targeting stress granules in ALS and frontotemporal dementia.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/377b05c0-93ba-48f7-8c9a-a0a129cb5fb1/Carrie_GZ.jpg</image:loc>
      <image:title>LAB MEMBERS - Carrie K.L. Tse ✉️ MPhil student</image:title>
      <image:caption>Carrie is WATCHING you</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/82ce0a5e-e850-4e27-abe5-84373ac94aaa/Jane.jpg</image:loc>
      <image:title>LAB MEMBERS - Jane Jingxuan Wang ✉️ MPhil student</image:title>
      <image:caption>Jane hold a Bachelor's degree in biological science from Nanjing University, and she is currently pursuing a Master's degree here, where she have deepened her understanding of AD. Her research interests lie in microglia and astrocyte's function in AD pathology.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/ecf59064-d0bd-4de4-9613-7cf5d8608608/Xi+Liu.jpg</image:loc>
      <image:title>LAB MEMBERS - Xi Liu ✉️ MPhil student</image:title>
      <image:caption>I am Liu Xi, holding a bachelor's degree from Central South University. My research focuses on the biochemical and biophysical properties of apolipoprotein E (apoE), with a particular interest in elucidating its structure and molecular interactions to better understand its role in Alzheimer's disease.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/373fca0f-ced8-4ff9-8089-cdb2babae3f2/XiangNing.jpg</image:loc>
      <image:title>LAB MEMBERS - Xiangning Li ✉️ MPhil student</image:title>
      <image:caption>Xiangning obtained her BSc degree of neurosience at the university of Edinburgh and completed her MRes degree at University College London. She started her MPhil study at Bu lab since 2025, with her research interest in the spatiotemporal dynamics of microglial phenotype transition during AD progression.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/78a6f02a-f987-486d-bdba-14985dd39d88/Xiaolu.jpg</image:loc>
      <image:title>LAB MEMBERS - Xiaolu Yang ✉️ MPhil student</image:title>
      <image:caption>Xiaolu finished his BSc of Life Science in CUHK. Currently, he is working at HKUST on the development of nanobodies targeting pathological ApoE, aiming to explore the new methods in the immunotherapies of Alzheimer’s disease. He is interested in revealing interactions between different molecules using biochemical methods.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/2b08d5b1-d01f-4cfc-a798-6436d84a59e1/Alex.jpg</image:loc>
      <image:title>LAB MEMBERS - Alex Ming Ho Lau ✉️ MPhil student</image:title>
      <image:caption>Alex received his BSc in Biotechnology and Business in 2025 from HKUST. He previously evaluated reliability of p-tau 217 as a blood-based biomarker for the early detection of Alzheimer’s disease in a mouse model. Now, he focuses on AD treatment. By evaluating the ability of different anti-ApoE antibodies in mouse models, he hopes to identify some suitable candidates for future development into human therapies.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/6be45134-9b88-4eef-9ab0-13f2cb38ae08/Qinwen.png</image:loc>
      <image:title>LAB MEMBERS - Qinwen Wang ✉️ MPhil student</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/c66f9955-df36-48ec-aa63-60668680b954/Brian.jpeg</image:loc>
      <image:title>LAB MEMBERS - Brian Tsz San Yim ✉️ MSc student</image:title>
      <image:caption>Hi, I’m Brian, a first-year MSc student in Biotechnology. I’m interested in the genetic and anatomical factors behind psychological disorders, and research on Alzheimer’s disease at the Bu Lab has greatly enriched my skills. Outside the lab, I love staying active with basketball, swimming, and boxing.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/17fddf85-679d-4dd7-a157-107fb6b38df1/Joe.jpg</image:loc>
      <image:title>LAB MEMBERS - Joe Zuming Liang ✉️ MSc student</image:title>
      <image:caption>Joe earned his BSc in 2025 and studied m6A and EMT in NPC integrating scRNA-seq and ML algorithms at Southern Medical University. He now focuses on APOE, LD, and their impact on the blood–brain barrier, aiming to uncover gene differences in AD and explore vascular cells.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/bcf00d7a-dcb4-47e2-bb03-3957b0b35635/Shuyang.jpg</image:loc>
      <image:title>LAB MEMBERS - Shuyang Yu ✉️ Visiting scholar</image:title>
      <image:caption>Shuyang is a neurologist from Beijing Tiantan Hospital, Capital Medical University. She came to Bu's lab as a visiting scholar for one year. Her research is about the contribution of different apoE variants and apoE receptors in alpha synyclein pathology.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/1771cc14-9d2e-45c2-bb35-97a15d3cf73d/Leon.jpeg</image:loc>
      <image:title>LAB MEMBERS - Tuen Shun Leon Cheung ✉️ Research assistant</image:title>
      <image:caption>I'm interested in the immunology of the brain  Walking around campus and touching grass is my hobby. Outside of the lab, I spend time with my dog at home.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/a64e94e5-cad4-4848-b719-890221ee965e/Candy.JPG</image:loc>
      <image:title>LAB MEMBERS - Candy Lau Chi Wing ✉️ UG student</image:title>
      <image:caption>Candy is a fourth-year student doing her final year project at the Bu lab. Her project focuses on tau pathology of Alzheimer’s disease. She doesn't want to die and wants to graduate.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/57ca19f8-ce31-45c3-b36d-a5ebef16c8e0/Kevin.jpg</image:loc>
      <image:title>LAB MEMBERS - Kevin Haochen Lai ✉️ UG student</image:title>
      <image:caption>Kevin is a fourth-year undergraduate student majoring in Biochemistry and Cell Biology. He is currently completing his final year project in the Bu Lab, focusing on investigating the effects of different ApoE variants on intracellular lipid metabolism.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.gbulab.com/contact-us</loc>
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    <lastmod>2025-10-02</lastmod>
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  <url>
    <loc>https://www.gbulab.com/focus</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2026-01-27</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/eea92b45-eafa-44df-b5bf-c8c32cb2fa12/APOE+cascade.png</image:loc>
      <image:title>Research Focus - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/e48f546b-968a-4cc7-88b7-31b1bd7706aa/Research+focus.png</image:loc>
      <image:title>Research Focus - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/c60045f8-e9f3-4777-a8dc-30e38dac4c49/Research+focus.png</image:loc>
      <image:title>Research Focus - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/459802c7-9233-4e71-8bf0-c32e14b668d8/Research+focus.png</image:loc>
      <image:title>Research Focus - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/7f74af36-7fd8-4dc4-a51b-74dd1c689834/Research+focus.png</image:loc>
      <image:title>Research Focus - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/478f5ab9-9b46-4f0d-8bf8-652b68fe7792/Research+focus.png</image:loc>
      <image:title>Research Focus - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/27c72a45-3a61-4ac1-9742-aabf1eca45bc/Research+focus.png</image:loc>
      <image:title>Research Focus - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.gbulab.com/modern-basil</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-10-16</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/58b47c8b59cc68eea9efaf22/1488317895565-TS2LYTL8YXNELU7RJTJT/IMG_4508.jpg</image:loc>
      <image:title>Modern Organic Thai</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.gbulab.com/member</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2026-01-27</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/9731e5e9-b9a4-42f7-bef1-3167ac61c54a/Jeff_v3.webp</image:loc>
      <image:title>Lab members - Jeff Y.L. Lam, PhD ✉️ University of Cambridge</image:title>
      <image:caption>Jeff investigates how Alzheimer’s disease develops at the molecular level, using state-of-the-art tools such as multi-omics and super-resolution microscopy. His research focuses on the biophysical and biochemical properties of apoE across in vitro and in vivo animal models, with the goal of elucidating how different apoE variants contribute to AD pathogenesis and progression.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/0c8ac9f1-c07a-404c-9909-5b978d9e403e/kai.jpg</image:loc>
      <image:title>Lab members - Kai Wang, PhD ✉️ The University of Tokyo</image:title>
      <image:caption>Kai grew up in Northeast China and obtained his Ph.D. from the University of Tokyo, where he studied the molecular mechanisms underlying protective gene variants in Alzheimer’s disease. In the Bu Lab, his research focuses on APOE protective variants and aims to elucidate their molecular and cellular mechanisms using iPSC-derived cells and animal models. Outside the lab, he enjoys cooking and exploring nature.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/1272d97f-7d18-4bea-b7f3-1d3dfeab3b28/IMG_1572.jpg</image:loc>
      <image:title>Lab members - Hao-Jie Chen, PhD ✉️ Beijing Normal University</image:title>
      <image:caption>Hao-Jie investigates how genetic and lifestyle factors shape the early development of Alzheimer’s disease, the leading cause of dementia. By integrating large-scale multimodal human data with functional experiments, he aims to advance APOE-targeted predictive models and therapeutic strategies to promote brain health and mental well-being in the ageing population.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/8a7e9ae1-9d07-4e14-9eaf-9ee96351e4b4/Mia.jpg</image:loc>
      <image:title>Lab members - Mia Yujing Liang ✉️ PhD student</image:title>
      <image:caption>This is Mia from Guangdong, Jiangmen. My projects are about evaluating the biochemical and biophysical patterns of artificially-generated apoE and cross-species apoE, paving the way to design for a super apoE as apoE-targeted gene therapy candidate.</image:caption>
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      <image:title>Lab members - Wenjun Zhang ✉️ PhD student</image:title>
      <image:caption>Wenjun received her M.S. from the University of Science and Technology of China. Her research focuses on iPSC-derived blood–brain barrier models and the peripheral effects of APOE on AD pathology.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/29f1466a-d7cb-4540-b0cd-bf620719d2eb/Zhiyuan.jpg</image:loc>
      <image:title>Lab members - Zhiyuan Ning ✉️ PhD student</image:title>
      <image:caption>Zhiyuan received his bachelor’s and master’s degree in Medicine from Sun Yat-Sen University. He investigates the roles of peripheral apoE using diverse approaches and animal models. His research also focuses on multi-omics analyses to explore the effects of APOE on Alzheimer’s disease, based on human samples and brain single-cell transcriptomes.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/9f07f4ae-57e1-4e00-b430-fc3bb841c4bb/yalin.jpg</image:loc>
      <image:title>Lab members - Yalin Zhu ✉️ Joint PhD student</image:title>
      <image:caption>Yalin earned her bachelor’s degree in biomedical engineering from Pennsylvania State University in 2017. She has contributed to the Greater Bay Area Healthy Aging Brain Study, and is studying APOE4-related biomarkers to enable the early detection of AD.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/6f3ca6f9-6e32-4a59-968e-2faaa4f3bbb5/cong+li.jpg</image:loc>
      <image:title>Lab members - Cong Li ✉️ Joint PhD student</image:title>
      <image:caption>Cong Li is a PhD student jointly trained by HKUST and Shenzhen Bay Laboratory. She obtained her master's degree from Sun Yat-sen University in 2022. Her research focuses on using Drosophila, iPSCs, and mice to develop potential therapeutic strategies targeting stress granules in ALS and frontotemporal dementia.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/f0002e80-e930-46e3-884e-794546bbac25/Carrie.jpg</image:loc>
      <image:title>Lab members - Carrie K.L. Tse ✉️ MPhil student</image:title>
      <image:caption>Carrie has obtained her bachelor’s degree in HKUST in 2024. Her research focuses on functional differences of apoE isoforms in choroid plexus and their related AD pathology. She likes privately stalking ppl from the lab.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/9f5d559d-8f8d-4947-beb9-3b13cdc07aa7/Jane.jpg</image:loc>
      <image:title>Lab members - Jane Jingxuan Wang ✉️ MPhil student</image:title>
      <image:caption>Jane holds a Bachelor's degree in biological science from Nanjing University, and she is currently pursuing a Master's degree here, where she have deepened her understanding of AD. Her research interests lie in microglia and astrocyte's function in AD pathology.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/efa378c3-8283-43d5-b98d-22baac603541/Liuxi.webp</image:loc>
      <image:title>Lab members - Xi Liu ✉️ MPhil student</image:title>
      <image:caption>I am Liu Xi, holding a bachelor's degree from Central South University. My research focuses on the biochemical and biophysical properties of apolipoprotein E (apoE), with a particular interest in elucidating its structure and molecular interactions to better understand its role in Alzheimer's disease.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/a5a10704-06ae-4b35-938f-c3845388d2c8/XiangNing.webp</image:loc>
      <image:title>Lab members - Xiangning Li ✉️ MPhil student</image:title>
      <image:caption>Xiangning obtained her BSc degree of neurosience at the university of Edinburgh and completed her MRes degree at University College London. She started her MPhil study at Bu lab since 2025, with her research interest in the spatiotemporal dynamics of microglial phenotype transition during AD progression.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/4bc12882-fa53-42c5-901b-858633232de7/Xiaolu.jpg</image:loc>
      <image:title>Lab members - Xiaolu Yang ✉️ MPhil student</image:title>
      <image:caption>Xiaolu finished his BSc of Life Science in CUHK. Currently, he is working at HKUST on the development of nanobodies targeting pathological ApoE, aiming to explore the new methods in the immunotherapies of Alzheimer’s disease. He is interested in revealing interactions between different molecules using biochemical methods.</image:caption>
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      <image:title>Lab members - Alex Ming Ho Lau ✉️ MPhil student</image:title>
      <image:caption>Alex received his BSc in Biotechnology and Business in 2025 from HKUST. He previously evaluated reliability of p-tau 217 as a blood-based biomarker for the early detection of Alzheimer’s disease in a mouse model. Now, he focuses on AD treatment. By evaluating the ability of different anti-ApoE antibodies in mouse models, he hopes to identify some suitable candidates for future development into human therapies.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/d137de8d-86c3-4fe0-9dd9-b7dd70bf0d6c/Leon.jpeg</image:loc>
      <image:title>Lab members - Tuen Shun Leon Cheung ✉️ MPhil student</image:title>
      <image:caption>Leon earned his BSc in Biochemistry and Cell Biology from HKUST. He pursued an MSc in Clinical Neuroscience at University College London (UCL), focusing on rare disease genetics. Now, he joins the Bu lab to study glial cell interactions in hopes of developing apoE-targeted cell therapies for sporadic Alzheimer’s Disease.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/926925f7-4ed5-4415-89ae-2fefe79744ea/Joe.jpg</image:loc>
      <image:title>Lab members - Joe Zuming Liang ✉️ MSc student</image:title>
      <image:caption>Joe earned his BSc in 2025 and studied m6A and EMT in NPC integrating scRNA-seq and ML algorithms at Southern Medical University. He now focuses on APOE, LD, and their impact on the blood–brain barrier, aiming to uncover gene differences in AD and explore vascular cells.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/d70162d1-ac10-43cd-8e97-ee610865bc4e/Mandy.webp</image:loc>
      <image:title>Lab members - Mandy C.M. Chan ✉️ Lab Manager</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/60b44b79-6171-4b63-aafa-c05fdc0c704b/Candy.JPG</image:loc>
      <image:title>Lab members - Candy Lau Chi Wing ✉️ UG student</image:title>
      <image:caption>Candy is a fourth-year student doing her final year project at the Bu lab. Her project focuses on tau pathology of Alzheimer’s disease. She doesn't want to die and wants to graduate.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/c6a59962-fc77-4ea8-9579-85a8895785ba/Kevin.jpg</image:loc>
      <image:title>Lab members - Kevin Haochen Lai ✉️ UG student</image:title>
      <image:caption>Kevin is a fourth-year undergraduate student majoring in Biochemistry and Cell Biology. He is currently completing his final year project in the Bu Lab, focusing on investigating the effects of different ApoE variants on intracellular lipid metabolism.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/a10a9d77-c69f-4816-8165-d81bc66041e5/Eric.jpg</image:loc>
      <image:title>Lab members - Eric Jiahong Xu ✉️ UG student</image:title>
      <image:caption>Eric is a first-year student enriching his research experience at the Bu lab. He loves thinking about complicated biological questions and is currently struggling hard to figure out his future research interests.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ca632fa29f2cc2b4802a5da/a2a44425-9c55-408a-a594-c8cf7e786814/Shuyang.jpg</image:loc>
      <image:title>Lab members - Shuyang Yu ✉️ Visiting scholar</image:title>
      <image:caption>Shuyang is a neurologist from Beijing Tiantan Hospital, Capital Medical University. She came to Bu's lab as a visiting scholar for one year. Her research is about the contribution of different apoE variants and apoE receptors in alpha synyclein pathology.</image:caption>
    </image:image>
  </url>
</urlset>

