Selective Loss of Cortical Endothelial Tight Junction Proteins During Alzheimer's Disease Progression
Citation: Yamazaki, Y., M. Shinohara, M. Shinohara, A. Yamazaki, M.E. Murray, A.M Liesinger, M.G. Heckman, E.R. Lesser, J.E. Parisi, R.C Petersen, D.W. Dickson, T. Kanekiyo, G. Bu (2019). “Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression.” Brain 142(4): 1077–1092.
APOE ε2 is Associated with Increased Tau Pathology in Primary Tauopathy
Citation:Zhao, N., C. C. Liu, A. J. Van Ingelgom, C. Linares, A. Kurti, J. A. Knight, M. G. Heckman, N. N. Diehl, M. Shinohara, Y. A. Martens, O. N. Attrebi, L. Petrucelli, J. D. Fryer, Z. K. Wszolek, N. R. Graff-Radford, R. J. Caselli, M. Y. Sanchez-Contreras, R. Rademakers, M. E. Murray, S. Koga, D. W. Dickson, O. A. Ross and G. Bu (2018). "APOE2 is associated with increased tau pathology in primary tauopathy." Nat Commun 9(1): 4388.
ApoE4 Accelerates Early Seeding of Amyloid Pathology.
Citation: Liu, C. C., N. Zhao, Y. Fu, N. Wang, C. Linares, C. W. Tsai and G. Bu (2017). "ApoE4 Accelerates Early Seeding of Amyloid Pathology." Neuron 96(5): 1024-1032 e1023.
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
Citation: Zhao, N., C. C. Liu, A. J. Van Ingelgom, Y. A. Martens, C. Linares, J. A. Knight, M. M. Painter, P. M. Sullivan and G. Bu (2017). "Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes." Neuron 96(1): 115-129 e115.
APOE ε4/ε4 Diminishes Neurotrophic Function of Human iPSC-Derived Astrocytes
Citation: Zhao, J., M. D. Davis, Y. A. Martens, M. Shinohara, N. R. Graff-Radford, S. G. Younkin, Z. K. Wszolek, T. Kanekiyo and G. Bu (2017). "APOE4/4 diminishes neurotrophic function of human iPSC-derived astrocytes." Hum Mol Genet 26(14): 2690-2700.
Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease
Citation: Zhao, N., C. C. Liu, W. Qiao and G. Bu (2018). "Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease." Biol Psychiatry 83(4): 347-357.
A novel link between trafficking and Lewy body disorders
Citation: Ross, O. A. and G. Bu (2018). "A novel link between trafficking and Lewy body disorders." Lancet Neurol 17(7): 571-573.
Soluble TREM2 induces inflammatory responses and enhances microglial survival
Citation: Zhong, L., X. F. Chen, T. Wang, Z. Wang, C. Liao, Z. Wang, R. Huang, D. Wang, X. Li, L. Wu, L. Jia, H. Zheng, M. Painter, Y. Atagi, C. C. Liu, Y. W. Zhang, J. D. Fryer, H. Xu and G. Bu (2017). "Soluble TREM2 induces inflammatory responses and enhances microglial survival." J Exp Med 214(3): 597-607.
Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-beta clearance and aggregation in Alzheimer's disease
Citation: Liu, C. C., N. Zhao, Y. Yamaguchi, J. R. Cirrito, T. Kanekiyo, D. M. Holtzman and G. Bu (2016). "Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-beta clearance and aggregation in Alzheimer's disease." Sci Transl Med 8(332): 332ra344.
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations
Citation: Shinohara, M., T. Kanekiyo, L. Yang, D. Linthicum, M. Shinohara, Y. Fu, L. Price, J. L. Frisch-Daiello, X. Han, J. D. Fryer and G. Bu (2016). "APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations." Ann Neurol 79(5): 758-774.
Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease
Citation: Liu, C. C., C. W. Tsai, F. Deak, J. Rogers, M. Penuliar, Y. M. Sung, J. N. Maher, Y. Fu, X. Li, H. Xu, S. Estus, H. S. Hoe, J. D. Fryer, T. Kanekiyo and G. Bu (2014). "Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease." Neuron 84(1): 63-77.
Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease
Citation: Shinohara, M., S. Fujioka, M. E. Murray, A. Wojtas, M. Baker, A. Rovelet-Lecrux, R. Rademakers, P. Das, J. E. Parisi, N. R. Graff-Radford, R. C. Petersen, D. W. Dickson and G. Bu (2014). "Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease." Brain 137(Pt 5): 1533-1549
Citation: Kanekiyo, T., H. Xu and G. Bu (2014). "ApoE and Abeta in Alzheimer's disease: accidental encounters or partners?" Neuron 81(4): 740-754.
ApoE and Abeta in Alzheimer's disease: accidental encounters or partners?
Brain regional correlation of amyloid-beta with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-beta accumulation
Citation: Shinohara, M., R. C. Petersen, D. W. Dickson and G. Bu (2013). "Brain regional correlation of amyloid-beta with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-beta accumulation." Acta Neuropathol 125(4): 535-547.
Citation: Liu, C. C., C. C. Liu, T. Kanekiyo, H. Xu and G. Bu (2013). "Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy." Nat Rev Neurol 9(2): 106-118.
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Citation: Liu, C. C., J. Prior, D. Piwnica-Worms and G. Bu (2010). "LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy." Proc Natl Acad Sci U S A 107(11): 5136-5141.
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
Citation: Bu, G. (2009). "Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy." Nat Rev Neurosci 10(5): 333-344.
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
Citation: Liu, Q., C. V. Zerbinatti, J. Zhang, H. S. Hoe, B. Wang, S. L. Cole, J. Herz, L. Muglia and G. Bu (2007). "Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1." Neuron 56(1): 66-78.